Ticagrelor

Ticagrelor: Uses Benefits & Side Effect

In the evolving world of cardiovascular medicine, Ticagrelor has emerged as a revolutionary antiplatelet medication. Its ability to reduce the risk of thrombotic cardiovascular events, particularly in patients with acute coronary syndromes (ACS), sets it apart as a critical drug in cardiology. At Valence Labs, we take pride in manufacturing high-qualityAPI and finished formulations that meet global standards, ensuring both safety and efficacy.

What is Ticagrelor?

Ticagrelor is an oral antiplatelet drug that belongs to a class of medications known as P2Y12 receptor antagonists. Unlike clopidogrel and prasugrel, Its  is reversible and does not require hepatic activation, offering a faster onset and more predictable platelet inhibition. It’s primarily used in combination with aspirin to prevent serious cardiovascular events such as heart attack or stroke in patients with ACS.

Chemical Properties of Ticagrelor:

• Molecular Formula: C23H28F2N6O4S
  
• Molecular Weight: 522.57 g/mol
  
• Mechanism of Action: Inhibits ADP-induced platelet aggregation via the P2Y12 receptor.
  
• Bioavailability: 36%
  
• Half-Life: Approximately 7 hours
  

Uses of Ticagrelor

Its is prescribed for:

• Acute Coronary Syndrome (ACS), including unstable angina and myocardial infarction (MI)
  
• Prevention of atherothrombotic events in patients with a history of heart attacks
  
• Secondary prevention of cardiovascular events in high-risk patients
  
• Prevention of stent thrombosis in patients undergoing percutaneous coronary intervention (PCI)
  

Advantages of Ticagrelor Over Other Antiplatelet Agents

1. Reversible Binding: Unlike clopidogrel, Its binds reversibly to the P2Y12 receptor, which allows faster recovery of platelet function after discontinuation.
2. No Genetic Dependence: Clopidogrel requires hepatic conversion, making its efficacy subject to genetic variability. Ticagrelor bypasses this, ensuring consistent platelet inhibition.
3. Rapid Onset of Action: Achieves peak plasma concentration within 1.5 hours, making it ideal for emergency use.
4. Superior Clinical Outcomes: The PLATO trial demonstrated better cardiovascular outcomes with its compared to clopidogrel in ACS patients.

Side Effects and Precautions

While Ticagrelor is highly effective, it is essential to understand its potential side effects:

Common Side Effects:

• Dyspnea (shortness of breath)
  
• Headache
  
• Dizziness
  
• Bleeding (mild to moderate)
  

Serious Side Effects:

• Severe bleeding
  
• Bradyarrhythmias (slow heart rate)
  
• Increased uric acid levels (hyperuricemia)
  

Precautions:

• Not recommended for patients with a history of intracranial hemorrhage.
  
• Should be used cautiously in patients with liver impairment.
  
• Avoid co-administration with strong CYP3A4 inhibitors or inducers.
  

Ticagrelor Dosage and Administration

Standard Adult Dosage:

• Loading Dose: 180 mg orally once
  
• Maintenance Dose: 90 mg twice daily with low-dose aspirin (75–100 mg)
  

Dosage may vary based on clinical condition, patient age, and physician guidance.

Why Choose Valence Labs for Ticagrelor?

At Valence Labs, we are committed to delivering pharmaceutical excellence. As a reputed manufacturer of Ticagrelor API and formulations, our state-of-the-art facility adheres to WHO-GMP, ISO, and cGMP certifications. Here’s why global clients choose Valence Labs:

1. Superior Quality Standards

We follow rigorous testing and validation at every production stage to ensure that our its products meet pharmacopoeial standards (USP/BP/EP/IP).

2. Advanced Manufacturing Facilities

Our modern infrastructure and highly qualified R&D team allow us to produce high-purity its with consistent batch-to-batch uniformity.

3. Global Supply Chain

Valence Labs supports exports to regulated and semi-regulated markets with all necessary documentation including DMF, COA, MSDS, and Regulatory Support.

4. Custom Formulations

We provide both bulk APIs and customized formulations (tablets) for clients involved in branded, generic, and contract manufacturing.

Market Outlook for Ticagrelor

With cardiovascular diseases being a leading cause of death globally, the market for antiplatelet drugs like Ticagrelor is witnessing steady growth. By 2028, the global market is expected to surpass $3 billion USD, driven by rising ACS incidence and awareness about preventive therapies.

As an innovative manufacturer, Valence Labs is well-positioned to contribute to this growth by offering cost-effective and high-quality its solutions to pharmaceutical companies worldwide.

Frequently Asked Questions (FAQs)

1. Q. What is Ticagrelor used for?
   Ans: Ticagrelor is primarily used to reduce the risk of heart attack, stroke, and cardiovascular death in patients with acute coronary syndromes (ACS) or a history of myocardial infarction.
2. Q. How does Ticagrelor differ from Clopidogrel?
   Ans: It does not require metabolic activation, acts faster, and has more consistent platelet inhibition than Clopidogrel. It also binds reversibly to the P2Y12 receptor.
3. Q. Can Ticagrelor be used long-term?
   Ans: It is generally prescribed for up to 12 months post-ACS, but some patients may be recommended to continue longer under medical supervision.
4. Q. Are there any drug interactions with Ticagrelor?
   Ans: Yes. Strong CYP3A4 inhibitors (like ketoconazole) and inducers (like rifampin) should be avoided. Concurrent use with other anticoagulants increases bleeding risk.
5. Q. Why should I choose Valence Labs for Ticagrelor API?
   Ans: Valence Labs ensures high-purity, GMP-compliant Ticagrelor with complete regulatory support and competitive pricing. Our advanced R&D and global network make us a trusted partner.
6. Q. Is Ticagrelor safe for use in elderly patients?
   Ans: Yes, but with caution. The risk of bleeding is slightly higher in elderly patients. Dosage adjustments and close monitoring may be required.

Conclusion:

As a healthcare company or distributor looking for a reliable Ticagrelor manufacturer, Valence Labs is your go-to partner. We provide bulk API supply, finished formulations, and third-party manufacturing services tailored to your business needs. Our products are compliant with international regulatory standards, and we maintain strict timelines for delivery.

Whether you’re catering to domestic markets or exporting globally, our cost-effective, high-efficacy it will strengthen your product portfolio and support better patient outcomes.

Contact Information

Contact Valence labs, if you want to get any details regarding Ticagrelor Or any other details regarding our company.

• Company Name: Valence Labs
• Company Address: Valence Labs Pvt Ltd, Village Jansui, Mirzapur-Jansui Road, Rajpura, Punjab 140401
• Phone Number: +91-98156 66305
• Email: info@valencelabs.co
• Website: www.valencelabs.co

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